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KMID : 1161420140170070758
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Journal of Medicinal Food
2014 Volume.17 No. 7 p.758 ~ p.763
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Protein Co-Ingestion Strongly Increases Postprandial Insulin Secretion in Type 2 Diabetes Patients
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Manders Ralph J. F.
Hansen Dominique
Zorenc Antoine H. G.
Dendale Paul
Kloek Joris
Saris Wim H. M.
van Loon Luc J. C.
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Abstract
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The capacity of nutritional protein to induce endogenous insulin secretion has been well established. However, it is not known whether such a response is applicable in a diverse population of type 2 diabetes patients. The aim of the present study was to assess the impact of co-ingesting either intact or hydrolyzed protein with carbohydrate on postprandial plasma insulin and glucose responses in type 2 diabetes patients. Sixty longstanding, male, type 2 diabetes patients participated in a study in which we determined postprandial plasma insulin and glucose responses after ingesting a single bolus of carbohydrate (0.7?g/kg: CHO) with or without an intact protein (0.3?g/kg: PRO) or its hydrolysate (0.3?g/kg: PROh). Results showed that protein co-ingestion strongly increased postprandial insulin release, with the insulin response +99±41 and +110±10% greater in the CHO+PRO and CHO+PROh experiments when compared with the CHO experiment. The insulinotropic properties of protein co-ingestion were evident in nearly all patients, with 58 out of 60 patients responding >10% when compared with the insulin response following carbohydrate ingestion only (CHO). The concomitant plasma glucose responses were 22±32 and 23±36% lower in the CHO+PRO and CHO+PROh experiments, respectively. We conclude that protein co-ingestion represents an effective dietary strategy to strongly augment postprandial insulin release and attenuate the postprandial rise in glucose concentration in type 2 diabetes patients.
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KEYWORD
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glucose, insulin, milk protein, protein hydrolysates
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